{"id":3778,"date":"2022-11-02T19:23:02","date_gmt":"2022-11-02T22:23:02","guid":{"rendered":"https:\/\/48xxyy.com.br\/?page_id=3778"},"modified":"2023-06-24T18:46:58","modified_gmt":"2023-06-24T21:46:58","slug":"endocrinologia","status":"publish","type":"page","link":"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/","title":{"rendered":"Endocrinologia"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3778\" class=\"elementor elementor-3778\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3d8a93d elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"3d8a93d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;waves-pattern&quot;,&quot;shape_divider_bottom&quot;:&quot;waves&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1047.1 3.7\" preserveAspectRatio=\"xMidYMin slice\">\n\t<path class=\"elementor-shape-fill\" d=\"M1047.1,0C557,0,8.9,0,0,0v1.6c0,0,0.6-1.5,2.7-0.3C3.9,2,6.1,4.1,8.3,3.5c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3C13.8,2,16,4.1,18.2,3.5c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3C23.6,2,25.9,4.1,28,3.5c0.9-0.2,1.5-1.9,1.5-1.9\tc0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3C63,2,65.3,4.1,67.4,3.5\tC68.3,3.3,69,1.6,69,1.6s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3\tC82.7,2,85,4.1,87.1,3.5c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3C92.6,2,94.8,4.1,97,3.5c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\tc0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\tc0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\tc0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\tc0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\tc0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\tc0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\ts0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9\tc0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9c0,0,0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2\tc0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3c1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.7-0.3\tc1.2,0.7,3.5,2.8,5.6,2.2c0.9-0.2,1.5-1.9,1.5-1.9s0.6-1.5,2.6-0.4V0z M2.5,1.2C2.5,1.2,2.5,1.2,2.5,1.2C2.5,1.2,2.5,1.2,2.5,1.2z M2.7,1.4c0.1,0,0.1,0.1,0.1,0.1C2.8,1.4,2.8,1.4,2.7,1.4z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M421.9,6.5c22.6-2.5,51.5,0.4,75.5,5.3c23.6,4.9,70.9,23.5,100.5,35.7c75.8,32.2,133.7,44.5,192.6,49.7\n\tc23.6,2.1,48.7,3.5,103.4-2.5c54.7-6,106.2-25.6,106.2-25.6V0H0v30.3c0,0,72,32.6,158.4,30.5c39.2-0.7,92.8-6.7,134-22.4\n\tc21.2-8.1,52.2-18.2,79.7-24.2C399.3,7.9,411.6,7.5,421.9,6.5z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f84e807\" data-id=\"f84e807\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-50c1f52 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"50c1f52\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-902b7c7\" data-id=\"902b7c7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-53cbdd2 meafe-dualheading-align-center elementor-widget elementor-widget-meafe-dualheading\" data-id=\"53cbdd2\" data-element_type=\"widget\" data-widget_type=\"meafe-dualheading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n        <div class=\"meafe-dual-header\">\n            <h1 class=\"title\">\n                <span class=\"main-header\">A s\u00edndrome na<\/span> \n                <span>Endocrinologia<\/span>\n            <\/h1>\n        <\/div>\n        \t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-306b83c elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"306b83c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25fb80d\" data-id=\"25fb80d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b02fd74 elementor-widget__width-auto elementor-absolute elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"b02fd74\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 18-06-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"146\" height=\"341\" src=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Vector1.png\" class=\"attachment-full size-full wp-image-2014\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Vector1.png 146w, https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Vector1-128x300.png 128w\" sizes=\"(max-width: 146px) 100vw, 146px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d34854 elementor-widget__width-auto elementor-absolute elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"4d34854\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"198\" height=\"299\" src=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Vector2.png\" class=\"attachment-full size-full wp-image-2024\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a361854 elementor-widget__width-auto elementor-absolute elementor-hidden-mobile elementor-invisible elementor-widget elementor-widget-image\" data-id=\"a361854\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"20\" height=\"20\" src=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Vectortt.png\" class=\"attachment-full size-full wp-image-1848\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b0909e elementor-widget__width-auto elementor-absolute elementor-hidden-mobile elementor-invisible elementor-widget elementor-widget-image\" data-id=\"2b0909e\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"29\" height=\"29\" src=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Misc_03.png\" class=\"attachment-full size-full wp-image-1580\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e47f041 elementor-widget__width-auto elementor-absolute elementor-hidden-mobile elementor-invisible elementor-widget elementor-widget-image\" data-id=\"e47f041\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"20\" height=\"20\" src=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Groupgg.png\" class=\"attachment-full size-full wp-image-1838\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e9cd29 elementor-widget__width-auto elementor-absolute elementor-hidden-mobile elementor-invisible elementor-widget elementor-widget-image\" data-id=\"3e9cd29\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"22\" height=\"23\" src=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Vector.png\" class=\"attachment-full size-full wp-image-1573\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4482801 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4482801\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1277152\" data-id=\"1277152\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-555570a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"555570a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-9b18eb2\" data-id=\"9b18eb2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-65f753b elementor-widget elementor-widget-text-editor\" data-id=\"65f753b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 18-06-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Como a altera\u00e7\u00e3o cromoss\u00f4mica est\u00e1 no par de cromossomos sexuais, \u00e9 natural que a s\u00edndrome tenha os efeitos mais sentidos na produ\u00e7\u00e3o dos horm\u00f4nios masculinos, sendo o principal deles a testosterona.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-58f2ecd elementor-widget-divider--separator-type-pattern elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"58f2ecd\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 18-06-2023 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;none&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 24 24&#039; fill=&#039;none&#039; stroke=&#039;black&#039; stroke-width=&#039;1&#039; stroke-linecap=&#039;square&#039; stroke-miterlimit=&#039;10&#039;%3E%3Cpath d=&#039;M0,6c6,0,0.9,11.1,6.9,11.1S18,6,24,6&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cd1fd30 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cd1fd30\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-09150c6\" data-id=\"09150c6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-a614286\" data-id=\"a614286\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a81381e elementor-widget elementor-widget-heading\" data-id=\"a81381e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 18-06-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Ossos e crescimento<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d4a333 elementor-widget elementor-widget-text-editor\" data-id=\"0d4a333\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Em palestra denominada Growth and Development in XXYY Boys, na confer\u00eancia sobre varia\u00e7\u00f5es de X e Y de 2009 em Los Angeles, o endocrinologista e geneticista argentino Rodolpho Rey mostrou como duas c\u00f3pias extras dos genes denominados SHOX se comportam no crescimento dos ossos.<\/p><p>Esses genes est\u00e3o nas partes superiores dos cromossomos X e Y e em boa parte das duplica\u00e7\u00f5es, eles ficam ativados. Eles carregam informa\u00e7\u00f5es\u00a0relacionadas \u00e0 quantidade de cartilagem que reveste a ponta dos ossos e que os permite crescer. Quanto mais cartilagem, maior a possibilidade de o indiv\u00edduo crescer.\u00a0<\/p><p>Quando o pediatra ou o endocrinologista pedem aquela radiografia da m\u00e3o para checar a idade \u00f3ssea de uma crian\u00e7a ou adolescente, o espa\u00e7o entre os ossos mostra, na verdade, o tanto de cartilagem que ainda deve &#8220;crescer&#8221; sendo transformada em osso. Ou seja, quanto mais os ossos das m\u00e3os est\u00e3o espa\u00e7ados (ou abertos) menor a idade \u00f3ssea e mais a crian\u00e7a ainda deve crescer. No caso dos meninos com 48 XXYY, a idade \u00f3ssea geralmente vem bem abaixo da idade cronol\u00f3gica, mesmo j\u00e1 sendo crian\u00e7as altas.<\/p><p>Na vida adulta, a cartilagem praticamente n\u00e3o existe mais. A regula\u00e7\u00e3o do crescimento come\u00e7a a acontecer na puberdade, que dura de tr\u00eas a cinco anos, com a incid\u00eancia do horm\u00f4nio que controla o &#8220;endurecimento&#8221; da cartilagem: a testosterona. Como a testosterona \u00e9 bastante reduzida ou at\u00e9 nula em indiv\u00edduos XXYY, esta \u00e9 a raz\u00e3o do crescimento exagerado dos portadores da s\u00edndrome.<\/p><p>No mundo inteiro, adolescentes com a s\u00edndrome de Klinefelter e variantes, como XXYY, s\u00e3o candidatos fortes \u00e0 terapia de reposi\u00e7\u00e3o hormonal de testosterona (TRT).<\/p><div id=\"accel-snackbar\" style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5682ee5 elementor-widget elementor-widget-heading\" data-id=\"5682ee5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Hipogonadismo<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a1e0964 elementor-widget elementor-widget-text-editor\" data-id=\"a1e0964\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Chamamos a redu\u00e7\u00e3o ou inatividade na secre\u00e7\u00e3o hormonal das g\u00f4nadas (test\u00edculos e ov\u00e1rios) de hipogonadismo.\u00a0<\/p><p>Essa baixa produ\u00e7\u00e3o de horm\u00f4nios pode ter duas origens distintas:\u00a0o tipo prim\u00e1rio\u00a0\u00e9 uma falha observada na produ\u00e7\u00e3o de testosterona dos test\u00edculos. As causas podem ser a s\u00edndrome de Klinefelter (e varia\u00e7\u00f5es), orquites (inflama\u00e7\u00e3o dos test\u00edculos), criptorquia (test\u00edculos retra\u00eddos) e outros.\u00a0<\/p><p>O<span style=\"background-color: var(--background-color); color: var(--primarycolor); font-family: var(--fontFamily); font-size: var(--fontSize); font-style: var(--fontStyle,inherit); font-weight: var(--fontWeight,normal); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform);\">\u00a0secund\u00e1rio \u00e9 proveniente do c\u00e9rebro, podendo ser causado por s\u00edndrome de Kallmann, tumor hipotal\u00e2mico ou pituit\u00e1rio, trauma cerebral e outros.<\/span><\/p><p>O hipogonadismo \u00e9 diagnosticado ap\u00f3s verifica\u00e7\u00e3o do serum T total e caso os sinais e sintomas cl\u00ednicos apontem para a condi\u00e7\u00e3o. Se o serum T total for menor que 300 ng\/dL2 o paciente \u00e9 considerado em hipogonadismo.<\/p><p>A Sociedade de Endocrinologia dos EUA aponta os seguintes sinais espec\u00edficos de hipogonadismo:<\/p><ul><li>Desenvolvimento sexual incompleto ou retardado;<\/li><li>Perda de p\u00ealos axilares e pubianos<\/li><li>Test\u00edculos com tamanho abaixo do verificado na popula\u00e7\u00e3o em geral.<\/li><\/ul><p>J\u00e1 os sinais inespec\u00edficos s\u00e3o:<\/p><ul><li>Menos energia e autoconfian\u00e7a<\/li><li>Sentimento de tristeza ou humor deprimido<\/li><li>Pouca mem\u00f3ria e concentra\u00e7\u00e3o<\/li><li>Dist\u00farbios do sono e sono diurno<\/li><li>anemia leve e sem outras causas<\/li><li>aumento da gordura corporal e do IMC<\/li><\/ul><div id=\"accel-snackbar\" style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e78ae40 elementor-widget elementor-widget-heading\" data-id=\"e78ae40\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Puberdade\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb7d639 elementor-widget elementor-widget-video\" data-id=\"fb7d639\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=XrY6UZj0-3w&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 18-06-2023 *\/\n.elementor-widget-video .elementor-widget-container{overflow:hidden;transform:translateZ(0)}.elementor-widget-video .elementor-wrapper{aspect-ratio:var(--video-aspect-ratio)}.elementor-widget-video .elementor-wrapper iframe,.elementor-widget-video .elementor-wrapper video{height:100%;width:100%;display:flex;border:none;background-color:#000}@supports not (aspect-ratio:1\/1){.elementor-widget-video .elementor-wrapper{position:relative;overflow:hidden;height:0;padding-bottom:calc(100% \/ var(--video-aspect-ratio))}.elementor-widget-video .elementor-wrapper iframe,.elementor-widget-video .elementor-wrapper video{position:absolute;top:0;right:0;bottom:0;left:0}}.elementor-widget-video .elementor-open-inline .elementor-custom-embed-image-overlay{position:absolute;top:0;left:0;width:100%;height:100%;background-size:cover;background-position:50%}.elementor-widget-video .elementor-custom-embed-image-overlay{cursor:pointer;text-align:center}.elementor-widget-video .elementor-custom-embed-image-overlay:hover .elementor-custom-embed-play i{opacity:1}.elementor-widget-video .elementor-custom-embed-image-overlay img{display:block;width:100%}.elementor-widget-video .e-hosted-video .elementor-video{-o-object-fit:cover;object-fit:cover}.e-con-inner>.elementor-widget-video,.e-con>.elementor-widget-video{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdf0d1d elementor-widget elementor-widget-text-editor\" data-id=\"bdf0d1d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Veja acima a entrevista da Dra Adriana Lofrano, endocrinologista do Hospital Universit\u00e1rio de Bras\u00edlia, ao nosso canal do Youtube, Papo de Cromossomos, sobre as principais quest\u00f5es relacionadas \u00e0 s\u00edndrome<\/p><p>A puberdade \u00e9 uma fase particularmente desafiadora para os portadores da S\u00edndrome XXYY. N\u00e3o s\u00f3 pela altura (estir\u00e3o) mas tamb\u00e9m pela reposi\u00e7\u00e3o hormonal e as quest\u00f5es ps\u00edquicas pr\u00f3prias da idade. Nesta palestra, a Dra. Nicole Tartaglia explica como e quando se d\u00e1 a reposi\u00e7\u00e3o hormonal:\u00a0<\/p><p><a href=\"https:\/\/www.youtube.com\/watch?v=Y-6wd6VPNlw\">Medical Problems and Medical Follow-up in XXYY Syndrome<\/a>\u00a0<\/p><p>Vale a pena conferir, porque \u00e9 uma das \u00fanicas palestras inteiramente dedicadas aos meninos com 48 cromossomos, sendo 2 X e 2 Y.<\/p><div id=\"accel-snackbar\" style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">\u00a0acima<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69033c1 elementor-widget elementor-widget-heading\" data-id=\"69033c1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Testosterona<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d7dc6f elementor-widget elementor-widget-text-editor\" data-id=\"9d7dc6f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Na \u00faltima confer\u00eancia sobre altera\u00e7\u00f5es cromoss\u00f4micas em Atlanta, a Dra Shanlee Davis disse que, nesta \u00e1rea, h\u00e1 uma similariedade de tratamento dos pacientes com XXYY e XXY, consideradas individualmente as demais caracter\u00edsticas f\u00edsicas que podem comprometer um pouco mais o primeiro grupo. Ela explicou que&nbsp;a primeira evid\u00eancia do aumento de testosterona \u00e9 o aumento dos test\u00edculos.&nbsp;<\/p>\n<p>Normalmente, a gl\u00e2ndula pituit\u00e1ria envia mensagens conhecidas como os horm\u00f4nios FSH e LH. O primeiro \u201cconversa\u201dcom as c\u00e9lulas dos test\u00edculos respons\u00e1veis por produzir o esperma. O LH, por sua vez, cobra a produ\u00e7\u00e3o de testosterona. Da mesma forma que a mensagem desce para os test\u00edculos, ela sobe na forma de feedback para a pituit\u00e1ria.<\/p>\n<p>No caso de uma produ\u00e7\u00e3o normal de testosterona, a pituit\u00e1ria mant\u00e9m o n\u00edvel desej\u00e1vel de LH para fazer a testosterona ir ocupando o corpo e a puberdade vai ocorrendo normalmente, sem necessidade de interven\u00e7\u00e3o.<\/p>\n<p>Os efeitos s\u00e3o vistos nos receptores de testosterona pelo corpo: a pele, os m\u00fasculos, as cordas vocais, mudan\u00e7as de humor, genit\u00e1lia e libido, fun\u00e7\u00f5es cerebrais, etc.<\/p>\n<p><span style=\"background-color: var(--background-color); color: var(--primaryColor); font-family: var(--fontFamily); font-size: var(--fontSize); font-style: var(--fontStyle,inherit); font-weight: var(--fontWeight,normal); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform);\">Na puberdade dos meninos com 48XXYY, a gl\u00e2ndula pituit\u00e1ria n\u00e3o recebe informa\u00e7\u00e3o de que a produ\u00e7\u00e3o de testosterona est\u00e1 normal, ent\u00e3o ela come\u00e7a a mandar cada vez mais \u201cmensagens\u201d, ou LH, para que os test\u00edculos produzam, produzam, produzam. E os test\u00edculos, muitas vezes conseguem produzir dentro do esperado por algum tempo, at\u00e9 que eventualmente deixam a produ\u00e7\u00e3o cair.<\/span><br><\/p>\n<p>Em m\u00e9dia, apesar de n\u00e3o haver dados espec\u00edficos para XXYY, um estudo da Dra Judy Ross mostrou que no primeiro ano de puberdade os meninos mantiveram horm\u00f4nios FSH subindo&nbsp; at\u00e9 acima da m\u00e9dia por um ano, e depois disso, houve a redu\u00e7\u00e3o.<\/p>\n<p>No caso do LH, o per\u00edodo de subida foi de dois anos desde o in\u00edcio da puberdade e depois vem a queda na produ\u00e7\u00e3o. Davis ressalta que cada caso \u00e9 \u00fanico, n\u00e3o significando que todos os adolescentes ter\u00e3o essas mesmas caracter\u00edsticas.<\/p>\n<p>O ideal, em termos de medi\u00e7\u00e3o, \u00e9 ter um LH relativamente baixo para uma testosterona compat\u00edvel. \u00c0 medida que o LH come\u00e7a a subir al\u00e9m do esperado, \u00e9 hora de considerar a reposi\u00e7\u00e3o de testosterona.<\/p>\n<p>Quais as diferen\u00e7as fundamentais da puberdade dos dois grupos? Com o estudo de Ross ficou patente que&nbsp;p\u00ealos pubianos tendem a aparecer&nbsp;antes do aumento dos test\u00edculos, a<span style=\"background-color: var(--background-color); color: var(--primarycolor); font-family: var(--fontFamily); font-size: var(--fontSize); font-style: var(--fontStyle,inherit); font-weight: var(--fontWeight,normal); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform);\">ssim como muitas vezes nas meninas os p\u00ealos aparecem antes do aumento dos seios nas meninas. Possivelmente a gl\u00e2ndula adrenal est\u00e1 produzindo horm\u00f4nios que produzem os p\u00ealos pubianos antes de test\u00edculos come\u00e7arem a efetiva produ\u00e7\u00e3o de testosterona.&nbsp;<\/span><\/p>\n<p>Mas nada \u00e9 uma regra. H\u00e1 crian\u00e7as que mostram uma produ\u00e7\u00e3o de testosterona em crescimento quando a gl\u00e2ndula adrenal ainda est\u00e1 \u201cdormente\u201d. A adrenal (tamb\u00e9m conhecida como suprarrenal) \u00e9&nbsp;coajuvante na testosterona \u2013 que t\u00eam nos test\u00edculos a principal produ\u00e7\u00e3o \u2013 mas ela \u00e9 fundamental em outras \u00e1reas de puberdade, como, por exemplo, na produ\u00e7\u00e3o de p\u00ealos e suor mais marcante, al\u00e9m de outras marcas de virilidade.<\/p>\n<div style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">&nbsp;<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8eae49 elementor-widget elementor-widget-heading\" data-id=\"a8eae49\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Quando come\u00e7ar a reposi\u00e7\u00e3o (TRT)<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9eb67fa elementor-widget elementor-widget-image\" data-id=\"9eb67fa\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/elementor\/thumbs\/pexels-jaroslaw-mis\u0301-106684-scaled-e1667839748143-pxdcrymx8wr80g5wds4nmmehhizrmpmpsndhwdt08g.jpg\" title=\"pexels-jaros\u0142aw-mis\u0301-106684\" alt=\"Mis JaroSlaw\/Pexels\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Mis JaroSlaw\/Pexels<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c403fd6 elementor-widget elementor-widget-text-editor\" data-id=\"c403fd6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>De acordo com os m\u00e9dicos&nbsp;Alan Rogol e Maria Vogiatzi, na confer\u00eancia da AXYS on line, em junho de 2021, alguns sinais s\u00e3o dados para que os pais e cuidadores levantem um sinal de alerta: comportamento disruptivo, fadiga, ginecomastia, contagem alta de LH e a pr\u00f3pria contagem de testosterona s\u00e3o indicativos, especialmente se forem simult\u00e2neos.&nbsp;<\/p>\n<p>De acordo com o endocrinologista e pesquisador Claus Gravhold, no mesmo semin\u00e1rio, o maior indicativo \u00e9 a alta produ\u00e7\u00e3o de LH. Mas ele mesmo avisa: outros m\u00e9dicos v\u00e3o esperar, al\u00e9m do pico do LH, a queda nos n\u00edveis da testosterona do pr\u00f3prio corpo.&nbsp;<\/p><p class=\"p1\"><span class=\"s1\">O estudo corrente Brains, Genes, And Puberty (BGAP) mostra que h\u00e1 significativas altera\u00e7\u00f5es no c\u00e9rebro que implicam altera\u00e7\u00f5es cognitivas tais como: habilidade em linguagem, disfun\u00e7\u00e3o motora, integra\u00e7\u00e3o visual-motora deficiente, mem\u00f3ria operacional, aten\u00e7\u00e3o e controle inibit\u00f3rio.<\/span><\/p><p class=\"p1\"><span class=\"s1\">A estrutura cerebral e suas c\u00e9lulas t\u00eam receptores que esperam descargas de testestorona. Quando esse horm\u00f4nio n\u00e3o vem, isso compromete o funcionamento da massa cinzenta, respons\u00e1vel pelo funcionamento cognitivo do indiv\u00edduo.<\/span><\/p>\n<div id=\"accel-snackbar\" style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">&nbsp;<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8a14093 elementor-widget elementor-widget-heading\" data-id=\"8a14093\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Efeitos da TRT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-822d980 elementor-widget elementor-widget-text-editor\" data-id=\"822d980\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>A busca por tratamento de testosterona come\u00e7ou em 1930 com a organoteratia, ou seja, a extra\u00e7\u00e3o e administra\u00e7\u00e3o de test\u00edculos de animais. Os primeiros medicamentos aprovados pela Food and Drug Administration (FDA) tinham uma f\u00f3rmula conhecida como 17-a-methil-T e mostravam, como efeito colateral, aumento de toxinas no f\u00edgado.<\/p><p>Foi a partir de 1990 que a terapia de reposi\u00e7\u00e3o de testosterona come\u00e7ou a se apresentar como a conhecemos hoje, por meio de inje\u00e7\u00f5es a cada duas semanas, testosterona intranasal, gel e adesivos de reposi\u00e7\u00e3o hormonal.\u00a0Alguns dos problemas relatados por pacientes desses tr\u00eas m\u00e9todos de reposi\u00e7\u00e3o incluem: a dor da inje\u00e7\u00e3o, o tempo para secagem do gel, irrita\u00e7\u00f5es na gengiva, irrita\u00e7\u00e3o nasal.<\/p><p>Uma das d\u00favidas centrais da comunidade de pais e cuidadores de Klinefelters e varia\u00e7\u00f5es \u00e9 sobre a reposi\u00e7\u00e3o de testosterona, seus benef\u00edcios e riscos. \u00c9 bom lembrar que, para o grupo desses pacientes, a reposi\u00e7\u00e3o \u00e9 feita a partir da adolesc\u00eancia e pode durar para toda a vida.<\/p><div id=\"accel-snackbar\" style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbb0098 elementor-widget elementor-widget-heading\" data-id=\"dbb0098\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Benef\u00edcios<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-327e01b elementor-widget elementor-widget-text-editor\" data-id=\"327e01b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Os m\u00e9dicos s\u00e3o quase un\u00e2nimes em dizer que a reposi\u00e7\u00e3o \u00e9 fundamental n\u00e3o s\u00f3 para os aspectos f\u00edsicos, mas para a sa\u00fade mental. Vogol, por exemplo, lembra que a testosternoa interfere de maneira positiva na sa\u00fade dos ossos, e Vogiatzi vai al\u00e9m afirmando que o tratamento \u00e9 um ganho em\u00a0densidade \u00f3ssea (o qu\u00e3o forte \u00e9 o osso) e, portanto, reduz riscos de fratura e de osteosporose.<\/p><p>Se o tratamento \u00e9 inciado tarde demais, os ossos podem ser mais fracos que o normal para o resto da vida. O mesmo efeito de \u201cperda de prazo\u201d pode ser sentido pelos pacientes com ginecomastia.\u00a0Claus Gravhold sustenta que\u00a0a administra\u00e7\u00e3o no per\u00edodo correto impede o desenvolvimento das mamas e pode colaborar para redu\u00e7\u00e3o da gordura abdominal.\u00a0Ele tamb\u00e9m menciona o efeito do horm\u00f4nio no c\u00e9rebro \u2013\u00a0especialmente para evitar a depress\u00e3o \u2013 e no sistema cardiovascular, protegendo o paciente dos riscos aumentados de trombose e embolia.<\/p><div id=\"accel-snackbar\" style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39282f2 elementor-widget elementor-widget-heading\" data-id=\"39282f2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Malef\u00edcios<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46ce4e1 elementor-widget elementor-widget-text-editor\" data-id=\"46ce4e1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Da mesma forma que o LH sobe e o corpo n\u00e3o produz testosterona para equilibrar essa \u201cbalan\u00e7a\u201d, o FSH, horm\u00f4nio ligado \u00e0 produ\u00e7\u00e3o de espermatoz\u00f3ides, tamb\u00e9m \u00e9 falho. Ou seja, a infertilidade \u00e9 quase uma regra na s\u00edndrome de Klinefelter e nas outras aneuploidias. Se existe alguma chance de produ\u00e7\u00e3o de espermatozoides, a reposi\u00e7\u00e3o de testosterona\u00a0dificulta ainda mais.<\/p><p>Na confer\u00eancia de 2021 da Axys, o urologista Peter Schlegel, da faculdade de Medicina da Universidade de Cornell, disse que a terapia de reposi\u00e7\u00e3o com testosterona apenas faz a produ\u00e7\u00e3o de espermatozoide diminuir. Talvez os efeitos da combina\u00e7\u00e3o de testosterona com anastrozole e hCG possa reduzir esse efeito colateral. Schlegel aconselha a retirada cir\u00fargica de espermatozoides antes do in\u00edcio da reposi\u00e7\u00e3o, embora reconhe\u00e7a que as taxas de sucesso em fertiliza\u00e7\u00e3o in vitro sejam pequenas com o material gen\u00e9tico, quando extra\u00eddo, e mesmo com a inje\u00e7\u00e3o inje\u00e7\u00e3o intracitoplasm\u00e1tica de espermatozoides (icsi).\u00a0<\/p><div id=\"accel-snackbar\" style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-334739e elementor-widget elementor-widget-heading\" data-id=\"334739e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Tipos de TRT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-97bf9f3 elementor-widget elementor-widget-text-editor\" data-id=\"97bf9f3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Inje\u00e7\u00f5es trimestrais, inje\u00e7\u00f5es di\u00e1rias subcut\u00e2neas, spray nasal,\u00a0gel dermatol\u00f3gico e, mais recentemente, comprimidos, s\u00e3o as formas normais de reposi\u00e7\u00e3o de testosterona. As mais comuns s\u00e3o as inje\u00e7\u00f5es e o gel, sendo que este \u00faltimo tem a maior fatia do mercado nos EUA para adultos.\u00a0\u00a0<\/p><p>Vogol n\u00e3o aconselha o uso do gel, no entanto, no caso dos adolescentes que come\u00e7am a TRT, pelo fato de a dose inicial ser bem menor do que o liberado em uma bombeada na embalagem. Para ele, essa possibilidade de gel deve ser considerada j\u00e1 em meados da puberdade, quando a dose vai aumentando de acordo com a necessidade do paciente.<\/p><p>Mesmo nas p\u00edlulas, segundo ele, a dose m\u00ednima seria grande demais para quem est\u00e1 iniciando o tratamento.\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28bae98 elementor-widget elementor-widget-heading\" data-id=\"28bae98\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">P\u00edlulas<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-de01d1d elementor-widget elementor-widget-image\" data-id=\"de01d1d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"199\" src=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-300x199.jpg\" class=\"attachment-medium size-medium wp-image-4116\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-300x199.jpg 300w, https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-1024x678.jpg 1024w, https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-768x509.jpg 768w, https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-370x247.jpg 370w, https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-270x180.jpg 270w, https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-1536x1017.jpg 1536w, https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-2048x1356.jpg 2048w, https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/pexels-pixabay-remedios-360x240.jpg 360w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Pixabay\/Pexels<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b6bc2d elementor-widget elementor-widget-text-editor\" data-id=\"7b6bc2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Sobre as p\u00edlulas, algumas marcas farmac\u00eauticas j\u00e1 est\u00e3o comercializando a testosterona oral nos Estados Unidos. Nesse caso, o\u00a0Undecanoato de Testosterona (TU) le \u00e9 administrado por meio de comprimidos duas vezes por dia (BID), durante a alimenta\u00e7\u00e3o.<\/p><p>Ele \u00e9 absorvido pelo intestino depois de carregado por lipoprote\u00ednas \u00e0s c\u00e9lulas linf\u00e1ticas desse \u00f3rg\u00e3o. No sistema linf\u00e1tico intestinal, o Jatenzo consegue pular (bypass) a primeira fase do metabolismo hep\u00e1tico, evitando sua inativa\u00e7\u00e3o. O TU tem uma alta concentra\u00e7\u00e3o lip\u00eddica (acido gorduroso) e por isso sua mol\u00e9cula \u00e9 reconhecida como gordura no pequeno intestino.<\/p><p>Uma vez que as esterases atingem o sistema circulat\u00f3rio, elas liberam o TU para o organismo.<\/p><p>O m\u00e9dico\u00a0Paresh Dandona, da State University of New York em Buffalo sobre o medicamento Jatenzo, da Clarus. A apresenta\u00e7\u00e3o foi divulgada no Endo2020, congresso online da Sociedade de Endocrinologia dos Estados Unidos em junho de 2020.\u00a0<span style=\"background-color: var(--background-color); color: var(--primarycolor); font-family: var(--fontFamily); font-size: var(--fontSize); font-style: var(--fontStyle,inherit); font-weight: var(--fontWeight,normal); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform);\">Link: <\/span><a style=\"font-family: var(--fontFamily); font-size: var(--fontSize); font-style: var(--fontStyle,inherit); font-weight: var(--fontWeight,normal); letter-spacing: var(--letterSpacing); text-transform: var(--textTransform);\" href=\"https:\/\/endoonline.endocrine.org\/pt-clarus\">https:\/\/endoonline.endocrine.org\/pt-clarus<\/a><\/p><p>Importante ressaltar que o medicamento ainda n\u00e3o est\u00e1 em comercializa\u00e7\u00e3o no Brasil e sua compra, nos Estados Unidos, requer receita emitida por m\u00e9dico associado aos conselhos profissionais daquele pa\u00eds.\u00a0<\/p><p>Com a receita correta, \u00e9 poss\u00edvel comprar por cerca de US$ 256,00\/ m\u00eas.<\/p><div id=\"accel-snackbar\" style=\"left: 50%; transform: translate(-50%, 0px); top: 50px;\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-2923e31\" data-id=\"2923e31\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A s\u00edndrome na Endocrinologia Como a altera\u00e7\u00e3o cromoss\u00f4mica est\u00e1 no par de cromossomos sexuais, \u00e9 natural que a s\u00edndrome tenha os efeitos mais sentidos na produ\u00e7\u00e3o dos horm\u00f4nios masculinos, sendo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3754,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_ti_tpc_template_sync":false,"_ti_tpc_template_id":""},"rishi__cb_customizer_meta":{"page_title_panel":"","page_title_hero_section":"default","breadcrumbs_single_page":"no","single_page_alignment":"left","single_page_margin":{"desktop":50,"tablet":30,"mobile":30},"51168eddaa576ac89d5d03a4497aabd8":"","page_structure_type":"default","d336ab799802197993eabfb64235ea76":"","content_style_source":"inherit","content_style":"box-layout","blog_page_streched_ed":"no","vertical_spacing_source":"custom","content_area_spacing":"none","single_page_content_background":{"background_type":"color","background_pattern":"type-1","background_image":{"attachment_id":null,"x":0,"y":0},"gradient":"linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%)","background_repeat":"no-repeat","background_size":"auto","background_attachment":"scroll","patternColor":{"default":{"color":"#e5e7ea"}},"overlayColor":{"default":{"color":"CT_CSS_SKIP_RULE"}},"backgroundColor":{"default":{"color":"var(--paletteColor5)"}}},"single_page_content_boxed_shadow":{"inherit":false,"blur":18,"spread":-6,"v_offset":12,"h_offset":0,"inset":false,"enable":false,"color":{"color":"rgba(34, 56, 101, 0.04)"}},"single_page_boxed_content_spacing":{"top":"40px","bottom":"40px","left":"40px","right":"40px","linked":true},"single_page_content_boxed_radius":{"top":"3px","bottom":"3px","left":"3px","right":"3px","linked":true},"48728b4a1b20beb9d0c47e57de904069":"","disable_featured_image":"no","disable_comments":"no","disable_header":"no","disable_footer":"no"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Endocrinologia - 48XXYY<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Endocrinologia - 48XXYY\" \/>\n<meta property=\"og:description\" content=\"A s\u00edndrome na Endocrinologia Como a altera\u00e7\u00e3o cromoss\u00f4mica est\u00e1 no par de cromossomos sexuais, \u00e9 natural que a s\u00edndrome tenha os efeitos mais sentidos na produ\u00e7\u00e3o dos horm\u00f4nios masculinos, sendo [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/\" \/>\n<meta property=\"og:site_name\" content=\"48XXYY\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/48xxyy\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-24T21:46:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Vector1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data1\" content=\"13 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/\",\"url\":\"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/\",\"name\":\"Endocrinologia - 48XXYY\",\"isPartOf\":{\"@id\":\"https:\/\/48xxyy.com.br\/#website\"},\"datePublished\":\"2022-11-02T22:23:02+00:00\",\"dateModified\":\"2023-06-24T21:46:58+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\/\/48xxyy.com.br\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Medicina\",\"item\":\"https:\/\/48xxyy.com.br\/index.php\/medicina\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Endocrinologia\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/48xxyy.com.br\/#website\",\"url\":\"https:\/\/48xxyy.com.br\/\",\"name\":\"48XXYY\",\"description\":\"Bem-vindo ao mundo dos X e Y extras\",\"publisher\":{\"@id\":\"https:\/\/48xxyy.com.br\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/48xxyy.com.br\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/48xxyy.com.br\/#organization\",\"name\":\"48XXYY\",\"url\":\"https:\/\/48xxyy.com.br\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\/\/48xxyy.com.br\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/urso-48xxtt-wpp.jpg\",\"contentUrl\":\"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/urso-48xxtt-wpp.jpg\",\"width\":400,\"height\":400,\"caption\":\"48XXYY\"},\"image\":{\"@id\":\"https:\/\/48xxyy.com.br\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/48xxyy\",\"https:\/\/www.instagram.com\/extraordynarios\/\",\"https:\/\/www.youtube.com\/channel\/UCNSbVYiYr-6IXrUbZvqsw4Q\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Endocrinologia - 48XXYY","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/","og_locale":"pt_BR","og_type":"article","og_title":"Endocrinologia - 48XXYY","og_description":"A s\u00edndrome na Endocrinologia Como a altera\u00e7\u00e3o cromoss\u00f4mica est\u00e1 no par de cromossomos sexuais, \u00e9 natural que a s\u00edndrome tenha os efeitos mais sentidos na produ\u00e7\u00e3o dos horm\u00f4nios masculinos, sendo [&hellip;]","og_url":"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/","og_site_name":"48XXYY","article_publisher":"https:\/\/www.facebook.com\/48xxyy","article_modified_time":"2023-06-24T21:46:58+00:00","og_image":[{"url":"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/02\/Vector1.png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. tempo de leitura":"13 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/","url":"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/","name":"Endocrinologia - 48XXYY","isPartOf":{"@id":"https:\/\/48xxyy.com.br\/#website"},"datePublished":"2022-11-02T22:23:02+00:00","dateModified":"2023-06-24T21:46:58+00:00","breadcrumb":{"@id":"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/48xxyy.com.br\/index.php\/medicina\/endocrinologia\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/48xxyy.com.br\/"},{"@type":"ListItem","position":2,"name":"Medicina","item":"https:\/\/48xxyy.com.br\/index.php\/medicina\/"},{"@type":"ListItem","position":3,"name":"Endocrinologia"}]},{"@type":"WebSite","@id":"https:\/\/48xxyy.com.br\/#website","url":"https:\/\/48xxyy.com.br\/","name":"48XXYY","description":"Bem-vindo ao mundo dos X e Y extras","publisher":{"@id":"https:\/\/48xxyy.com.br\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/48xxyy.com.br\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"pt-BR"},{"@type":"Organization","@id":"https:\/\/48xxyy.com.br\/#organization","name":"48XXYY","url":"https:\/\/48xxyy.com.br\/","logo":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/48xxyy.com.br\/#\/schema\/logo\/image\/","url":"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/urso-48xxtt-wpp.jpg","contentUrl":"https:\/\/48xxyy.com.br\/wp-content\/uploads\/2022\/11\/urso-48xxtt-wpp.jpg","width":400,"height":400,"caption":"48XXYY"},"image":{"@id":"https:\/\/48xxyy.com.br\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/48xxyy","https:\/\/www.instagram.com\/extraordynarios\/","https:\/\/www.youtube.com\/channel\/UCNSbVYiYr-6IXrUbZvqsw4Q"]}]}},"_links":{"self":[{"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/pages\/3778"}],"collection":[{"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/comments?post=3778"}],"version-history":[{"count":43,"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/pages\/3778\/revisions"}],"predecessor-version":[{"id":5082,"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/pages\/3778\/revisions\/5082"}],"up":[{"embeddable":true,"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/pages\/3754"}],"wp:attachment":[{"href":"https:\/\/48xxyy.com.br\/index.php\/wp-json\/wp\/v2\/media?parent=3778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}